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KMID : 1197720170100020069
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대한파킨슨병 및 이상운동질환 학회지
2017 Volume.10 No. 2 p.69 ~ p.79
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Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson’s Disease
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Si Xiaoli
Pu Jiali
Zhang Baorong
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Abstract
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Parkinson’s disease (PD), the second most common neurodegenerative disorder after Alzheimer’s disease, is characterized by the loss of nigral dopaminergic neurons. PD leads to a series of clinical symptoms, including motor and non-motor disturbances. α-synuclein, the major component of Lewy bodies, is a hallmark lesion in PD. In this review, we concentrate on presenting the latest research on the structure, distribution, and function of α-synuclein, and its interactions with PD. We also summarize the clinic applications of α-synuclein, which suggest its use as a biomarker, and the latest progress in α-synuclein therapy.
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KEYWORD
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Parkinson’s disease, alpha-synuclein, pathogenic mechanism, biomarker, therapeutic strategy
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